Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation

Data presented in this week's issue of Blood shed new light on the interaction between lipoproteins and platelets that may lead to heart attack. In the manuscript, Chan and colleagues report that L5, the most highly electronegative fraction of low-density lipoprotein (LDL), is markedly elevated in patients with ST-elevation myocardial infarction (STEMI). Utilizing in vitro studies, investigators demonstrate that L5 increased adenosine diphosphate (ADP)-induced platelet aggregation, platelet P-selectin expression, GPIIb/IIIa activation, and platelet-endothelial cell adhesion. via Health News from Medical News Today Read More Here..

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