Valuable conditional mouse models generated by CRISPR/Cas genome engineering system

Whitehead Institute researchers have used the gene regulation system CRISPR/Cas to engineer mouse genomes containing reporter and conditional alleles in one step. Animals containing such sophisticated engineered alleles can now be made in a matter of weeks rather than years and could be used to model diseases and study gene function. "We've used CRISPR/Cas to mutate genes before, but the nature of the targeted mutations has been unpredictable," says Whitehead Founding Member Rudolf Jaenisch. "Now we can make specific deletions defined by two cuts... via Health News from Medical News Today Read More Here..

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