Fear-related behaviours and anxiety disorders: where and how are they controlled?

A team of researchers at Inserm led by Cyril Herry (Inserm Unit 862, "Neurocentre Magendie," Bordeaux) has just shown that interneurons located in the forebrain at the level of the prefrontal cortex are heavily involved in the control of fear responses. Using an approach combining in vivo recordings and optogenetic manipulations in mice, the researchers succeeded in showing that the inhibition of parvalbumin-expressing prefrontal interneurons triggers a chain reaction resulting in fear behaviour. via Health News from Medical News Today Read More Here..

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