One in five American adults in a commercially insured plan were given prescriptions for short term use of oral corticosteroids during a three year period, with an associated increased risk of adverse events. Of 1.5 million adults, 21% received at least 1 prescription for oral corticosteroids over 3 period.
The most common indications for use were:
- upper respiratory tract infections
- spinal conditions
Within 30 days of drug initiation, there was an increase in rates of:
- venous thromboembolism
Risk over the subsequent 31–90 days.
The increased risk persisted at prednisone equivalent doses of less than 20 mg/day.
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