Aortic aneurysm may be a risk factor for those with Loeys-Dietz syndrome. LDS results in the presence of missense mutations within either of the genes encoding receptors for TGF- (and) #946;. LDS-associated mutations are predicted to reduce TGF- (and) #946; signaling; however, aortic tissue samples from LDS patients indicate that TGF- (and) #946; signaling may be enhanced. In this issue of the iJournal of Clinical Investigation/i, Harry Dietz and colleagues at Johns Hopkins School ...Sunday, 22 December 2013
Loeys-Dietz Syndrome Associated With a Higher Risk of Aortic Aneurysm
Aortic aneurysm may be a risk factor for those with Loeys-Dietz syndrome. LDS results in the presence of missense mutations within either of the genes encoding receptors for TGF- (and) #946;. LDS-associated mutations are predicted to reduce TGF- (and) #946; signaling; however, aortic tissue samples from LDS patients indicate that TGF- (and) #946; signaling may be enhanced. In this issue of the iJournal of Clinical Investigation/i, Harry Dietz and colleagues at Johns Hopkins School ...
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