'RNA Sponge' Mechanism may Cause ALS/FTD Neurodegeneration: Research

An alteration in the gene C9orf72 was recently identified as the most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia). But how the mutation causes neurodegenerative disease appeared mysterious. Researchers at Emory University School of Medicine have demonstrated that this ALS/FTD mutation may be harmful because it creates an "RNA sponge," soaking up an important regulatory protein that binds RNA. The ...

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