Researchers Exploring Methods To Combat Drug-resistant Cancers

Activating proteins like Caspase-3 (CASP3) that promote cell death is the main factor behind many cancer therapies. Several forms of cancer develop resistance to these drugs by down regulating CASP3 through an unknown mechanism. In the absence of CASP3, tumor cells produce another cell death promoting protein CASP7, but it is rendered inactive by the X-linked inhibitor of apoptosis protein (XIAP). In this issue of the iJournal of Clinical Investigation/i, ...

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